Pagina Iniziale » Pancreas » Linee Guida Tumore Pancreas
Principali Linee Guida per il Tumore del Pancreas
In questa pagina sono raccolte e (tentativamente) sempre aggiornate le principali linee guida nazionali ed internazionali sulla diagnosi ed il trattamento del tumore del pancreas.
In particolare vi sono quelle di interesse chirurgico.
La consultazione di qualcuna fra le linea guida qui elencate potrebbe non essere offerta in maniera gratuita dal sito dell’editore del giornale scientifico che l’ha pubblicata.
Seleziona, aprendo il menù, la categoria di Linee Guida che vuoi vedere:
- Epatocarcinoma
- Colangiocarcinoma
- Metastasi
- Tumori Benigni Fegato
- Chirurgia Epatica
- Resezioni Laparo
- Resezioni Robotiche
- Trapianto Fegato
- ERAS Chirurgia Fegato
- Tumore Colecisti
- Calcoli Colecisti
- Polipi Colecisti
- Colangite Acuta
- Danni Via Biliare
- Tumore del Pancreas
- IPMN – Tumori Cistici Pancreas
- Pancreatite Acuta
- Chirurgia Pancreas
- ERAS Pancreas
- Traumi Fegato
- Esami Fegato
- Diagnosi Lesioni Focali Epatiche
- Centro di Chirurgia HBP
- Storia Chirurgia Epatobiliare
- Tutte le Linee Guida
2023
Springfeld C; Ferrone C R; Katz M H G; Philip P A; Hong T S; Hackert T; Büchler M W; Neoptolemos J
Neoadjuvant therapy for pancreatic cancer Journal Article
In: Nat. Rev. Clin. Oncol., 2023.
@article{Springfeld2023-zi,
title = {Neoadjuvant therapy for pancreatic cancer},
author = {Christoph Springfeld and Cristina R Ferrone and Matthew H G Katz and Philip A Philip and Theodore S Hong and Thilo Hackert and Markus W Büchler and John Neoptolemos},
url = {https://www.nature.com/articles/s41571-023-00746-1.pdf
},
doi = {https://doi.org/10.1038/s41571-023-00746-1},
year = {2023},
date = {2023-03-01},
urldate = {2023-03-01},
journal = {Nat. Rev. Clin. Oncol.},
abstract = {Patients with localized pancreatic ductal adenocarcinoma (PDAC)
are best treated with surgical resection of the primary tumour
and systemic chemotherapy, which provides considerably longer
overall survival (OS) durations than either modality alone.
Regardless, most patients will have disease relapse owing to
micrometastatic disease. Although currently a matter of some
debate, considerable research interest has been focused on the
role of neoadjuvant therapy for all forms of resectable PDAC.
Whilst adjuvant combination chemotherapy remains the standard of
care for patients with resectable PDAC, neoadjuvant chemotherapy
seems to improve OS without necessarily increasing the resection
rate in those with borderline-resectable disease. Furthermore,
around 20% of patients with unresectable non-metastatic PDAC
might undergo resection following 4-6 months of induction
combination chemotherapy with or without radiotherapy, even in
the absence of a clear radiological response, leading to improved
OS outcomes in this group. Distinct molecular and biological
responses to different types of therapies need to be better
understood in order to enable the optimal sequencing of specific
treatment modalities to further improve OS. In this Review, we
describe current treatment strategies for the various clinical
stages of PDAC and discuss developments that are likely to
determine the optimal sequence of multimodality therapies by
integrating the fundamental clinical and molecular features of
the cancer.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
are best treated with surgical resection of the primary tumour
and systemic chemotherapy, which provides considerably longer
overall survival (OS) durations than either modality alone.
Regardless, most patients will have disease relapse owing to
micrometastatic disease. Although currently a matter of some
debate, considerable research interest has been focused on the
role of neoadjuvant therapy for all forms of resectable PDAC.
Whilst adjuvant combination chemotherapy remains the standard of
care for patients with resectable PDAC, neoadjuvant chemotherapy
seems to improve OS without necessarily increasing the resection
rate in those with borderline-resectable disease. Furthermore,
around 20% of patients with unresectable non-metastatic PDAC
might undergo resection following 4-6 months of induction
combination chemotherapy with or without radiotherapy, even in
the absence of a clear radiological response, leading to improved
OS outcomes in this group. Distinct molecular and biological
responses to different types of therapies need to be better
understood in order to enable the optimal sequencing of specific
treatment modalities to further improve OS. In this Review, we
describe current treatment strategies for the various clinical
stages of PDAC and discuss developments that are likely to
determine the optimal sequence of multimodality therapies by
integrating the fundamental clinical and molecular features of
the cancer.
Maggino L; Malleo G; Crippa S; Belfiori G; Nobile S; Gasparini G; Lionetto G; Luchini C; Mattiolo P; Schiavo-Lena M; Doglioni C; Scarpa A; Bassi C; Falconi M; Salvia R
In: Annals of Surgical Oncology, vol. 30, no. 1, pp. 207 – 219, 2023, ISSN: 10689265, (Cited by: 1; All Open Access, Green Open Access, Hybrid Gold Open Access).
@article{Maggino2023207,
title = {CA19.9 Response and Tumor Size Predict Recurrence Following Post-neoadjuvant Pancreatectomy in Initially Resectable and Borderline Resectable Pancreatic Ductal Adenocarcinoma},
author = {Laura Maggino and Giuseppe Malleo and Stefano Crippa and Giulio Belfiori and Sara Nobile and Giulia Gasparini and Gabriella Lionetto and Claudio Luchini and Paola Mattiolo and Marco Schiavo-Lena and Claudio Doglioni and Aldo Scarpa and Claudio Bassi and Massimo Falconi and Roberto Salvia},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85139743479&doi=10.1245%2fs10434-022-12622-w&partnerID=40&md5=37a355ed15c5f8bfc23e130604180fe8},
doi = {10.1245/s10434-022-12622-w},
issn = {10689265},
year = {2023},
date = {2023-01-01},
urldate = {2023-01-01},
journal = {Annals of Surgical Oncology},
volume = {30},
number = {1},
pages = {207 – 219},
publisher = {Springer Science and Business Media Deutschland GmbH},
abstract = {Background: Data on recurrence after post-neoadjuvant pancreatectomy are scant. This study investigated the incidence and pattern of recurrence in patients with initially resectable and borderline resectable pancreatic ductal adenocarcinoma who received post-neoadjuvant pancreatectomy. Furthermore, preoperative predictors of recurrence-free survival (RFS) and their interactions were determined. Patients and Methods: Patients undergoing post-neoadjuvant pancreatectomy at two academic facilities between 2013 and 2017 were analyzed using standard statistics. The possible interplay between preoperative parameters was scrutinized including interaction terms in multivariable Cox models. Results: Among 315 included patients, 152 (48.3%) were anatomically resectable. The median RFS was 15.7 months, with 1- and 3-year recurrence rates of 41.9% and 74.2%, respectively. Distant recurrence occurred in 83.3% of patients, with lung-only patterns exhibiting the most favorable prognostic outlook. Normal posttreatment CA19.9, ΔCA19.9 (both in patients with normal and elevated baseline levels), and posttreatment tumor size were associated with RFS. Critical thresholds for ΔCA19.9 and tumor size were set at 50% and 20 mm, respectively. Interaction between ΔCA19.9 and posttreatment CA19.9 suggested a significant risk reduction in patients with elevated values when ΔCA19.9 exceeded 50%. Moreover, posttreatment tumor size interacted with posttreatment CA19.9 and ΔCA19.9, suggesting an increased risk in the instance of elevated posttreatment CA19.9 values and a protective effect associated with CA19.9 response in patients with tumor size >20 mm. Conclusion: Recurrence following post-neoadjuvant pancreatectomy is common. Preoperative tumor size <20 mm, normal posttreatment CA19.9 and ΔCA19.9 > 50% were associated with longer RFS. These variables should not be taken in isolation, as their interaction significantly modulates the recurrence risk. © 2022, The Author(s).},
note = {Cited by: 1; All Open Access, Green Open Access, Hybrid Gold Open Access},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Liang T; Zhang Q; Wu G; Liu C; Bai X; Gao S; Ma T; Sun K; Yan S; Xiao W; Jiang T; Lu F; Zhang Y; Shen Y; Zhang M; Zhang X; Shan J
In: Ann. Surg., 2023.
@article{Liang2023-xh,
title = {Radical resection combined with intestinal autotransplantation for locally advanced pancreatic cancer after neoadjuvant therapy: A report of 36 consecutive cases},
author = {Tingbo Liang and Qi Zhang and Guosheng Wu and Chaoxu Liu and Xueli Bai and Shunliang Gao and Tao Ma and Ke Sun and Senxiang Yan and Wenbo Xiao and Tian'an Jiang and Fangyan Lu and Yuntao Zhang and Yan Shen and Min Zhang and Xiaochen Zhang and Jianzhen Shan},
doi = {10.1097/SLA.0000000000005797},
year = {2023},
date = {2023-01-01},
urldate = {2023-01-01},
journal = {Ann. Surg.},
abstract = {OBJECTIVE: The aim of this study was to achieve radical resection
of locally advanced pancreatic ductal adenocarcinoma (PDAC), and
tested the safety and benefits of intestinal autotransplantation
in pancreatic surgery. BACKGROUND: PDAC has extremely dismal
prognosis. Radical resection was proved to improve prognosis of
patients with PDAC; however, locally advanced disease had a very
low resection rate currently. We explored and evaluated whether
the combination of modern advances in systemic treatment and this
microinvasive surgery was feasible in clinical practice. METHODS:
Patients diagnosed as PDAC with superior mesenteric artery (SMA)
involvement and with or without coeliac trunk involvement were
included. Patients were treated with modified-FOLFIRINOX
chemotherapy with or without anti-PD-1 antibodies, and were
applied to tumor resection combined with intestinal
autotransplantation. Data of operative parameters, pathological
results, mortality, morbidity, and survival were analyzed.
RESULTS: A total of 36 consecutive cases were applied to this
strategy and underwent radical resection combined with intestinal
autotransplantation. Among these patients, 24 of them received
Whipple procedure, eleven patients received total pancreatectomy,
and the other one patient received distal pancreatectomy. The
median operation time was 539 minutes. Postoperative pathology
showed R0 resection rate of 94.4%, and tumor invasion of SMA or
SMV was confirmed in 32 patients. The median number of dissected
lymph nodes was 43, and 25 patients were positive for lymph nodes
metastasis. The median time of Intensive Care Unit stay was four
days. Two patients died within 30 days after surgery due to
multi-organ failure. The severe postoperative adverse events
(equal or higher than grade 3) was observed in 12 out of 36
patients, and diarrhea, gastroparesis, and abdominal infection
were the most frequent adverse events. Postoperative hospital
stay was averagely 34 days. The recurrence-free survival is 13.6
months. The median overall survival of patients after diagnosis
and after surgery were 21.4 months and 14.5 months, respectively.
CONCLUSIONS: Our attempt suggests safety of this modality and may
be clinically beneficial for highly-selected patients with PDAC.
However, experience of multidisciplinary pancreatic cancer care
and intestinal transplantation is warranted.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
of locally advanced pancreatic ductal adenocarcinoma (PDAC), and
tested the safety and benefits of intestinal autotransplantation
in pancreatic surgery. BACKGROUND: PDAC has extremely dismal
prognosis. Radical resection was proved to improve prognosis of
patients with PDAC; however, locally advanced disease had a very
low resection rate currently. We explored and evaluated whether
the combination of modern advances in systemic treatment and this
microinvasive surgery was feasible in clinical practice. METHODS:
Patients diagnosed as PDAC with superior mesenteric artery (SMA)
involvement and with or without coeliac trunk involvement were
included. Patients were treated with modified-FOLFIRINOX
chemotherapy with or without anti-PD-1 antibodies, and were
applied to tumor resection combined with intestinal
autotransplantation. Data of operative parameters, pathological
results, mortality, morbidity, and survival were analyzed.
RESULTS: A total of 36 consecutive cases were applied to this
strategy and underwent radical resection combined with intestinal
autotransplantation. Among these patients, 24 of them received
Whipple procedure, eleven patients received total pancreatectomy,
and the other one patient received distal pancreatectomy. The
median operation time was 539 minutes. Postoperative pathology
showed R0 resection rate of 94.4%, and tumor invasion of SMA or
SMV was confirmed in 32 patients. The median number of dissected
lymph nodes was 43, and 25 patients were positive for lymph nodes
metastasis. The median time of Intensive Care Unit stay was four
days. Two patients died within 30 days after surgery due to
multi-organ failure. The severe postoperative adverse events
(equal or higher than grade 3) was observed in 12 out of 36
patients, and diarrhea, gastroparesis, and abdominal infection
were the most frequent adverse events. Postoperative hospital
stay was averagely 34 days. The recurrence-free survival is 13.6
months. The median overall survival of patients after diagnosis
and after surgery were 21.4 months and 14.5 months, respectively.
CONCLUSIONS: Our attempt suggests safety of this modality and may
be clinically beneficial for highly-selected patients with PDAC.
However, experience of multidisciplinary pancreatic cancer care
and intestinal transplantation is warranted.
Broek B L J; Zwart M J W; Bonsing B A; Busch O R; Dam J L; Hingh I H J T; Hogg M E; Luyer M D; Mieog J S D; Stibbe L A; Takagi K; Tran T C K; Wilde R F; 3rd Zeh H J; Zureikat A H; Koerkamp B G; Besselink M G; Group D P C
In: Ann. Surg., 2023.
@article{Van_den_Broek2023-od,
title = {Video grading of pancreatic anastomoses during robotic pancreatoduodenectomy to assess both learning curve and the risk of pancreatic fistula - A post hoc analysis of the LAELAPS-3 training program},
author = {Bram L J Broek and Maurice J W Zwart and Bert A Bonsing and Olivier R Busch and Jacob L Dam and Ignace H J T Hingh and Melissa E Hogg and Misha D Luyer and J S D Mieog and Luna A Stibbe and Kosei Takagi and T C K Tran and Roeland F Wilde and Herbert J 3rd Zeh and Amer H Zureikat and Bas Groot Koerkamp and Marc G Besselink and Dutch Pancreatic Cancer Group},
doi = {10.1097/SLA.0000000000005796},
year = {2023},
date = {2023-01-01},
urldate = {2023-01-01},
journal = {Ann. Surg.},
abstract = {OBJECTIVE: To assess the learning curve of pancreaticojejunostomy
during robotic pancreatoduodenectomy(RPD) and to predict the risk
of postoperative pancreatic fistula(POPF) by using the objective
structured assessment of technical skills(OSATS) score, taking
the fistula risk score into account. SUMMARY BACKGROUND DATA: RPD
is a challenging procedure that requires extensive training and
confirmation of adequate surgical performance. Video grading,
modified for RPD, of the pancreatic anastomosis could assess the
learning curve of RPD and predict the risk of POPF. METHODS:
Post-hoc assessment of patients prospectively included in four
Dutch centers in a nationwide LAELAPS-3 training program for RPD.
Video grading of the pancreaticojejunostomy was performed by two
graders using OSATS (attainable scores 12-60). The main outcomes
were the combined OSATS of the two graders and POPF (grade B/C).
CUSUM analyzed a turning point in the learning curve for surgical
skill. Logistic regression determined the cut-off for OSATS.
Patients were categorized for POPF risk (i.e. low, intermediate,
high) based on the updated alternative fistula risk scores
(uaFRS). RESULTS: Videos from 153 pancreatic anastomoses were
included. Median OSATS score was 48 (IQR 41-52) points and with a
turning point at 33 procedures. POPF occurred in 39 patients
(25.5%). An OSATS score below 49, present in 77 patients
(50.3%), was associated with an increased risk of POPF, OR 4.0},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
during robotic pancreatoduodenectomy(RPD) and to predict the risk
of postoperative pancreatic fistula(POPF) by using the objective
structured assessment of technical skills(OSATS) score, taking
the fistula risk score into account. SUMMARY BACKGROUND DATA: RPD
is a challenging procedure that requires extensive training and
confirmation of adequate surgical performance. Video grading,
modified for RPD, of the pancreatic anastomosis could assess the
learning curve of RPD and predict the risk of POPF. METHODS:
Post-hoc assessment of patients prospectively included in four
Dutch centers in a nationwide LAELAPS-3 training program for RPD.
Video grading of the pancreaticojejunostomy was performed by two
graders using OSATS (attainable scores 12-60). The main outcomes
were the combined OSATS of the two graders and POPF (grade B/C).
CUSUM analyzed a turning point in the learning curve for surgical
skill. Logistic regression determined the cut-off for OSATS.
Patients were categorized for POPF risk (i.e. low, intermediate,
high) based on the updated alternative fistula risk scores
(uaFRS). RESULTS: Videos from 153 pancreatic anastomoses were
included. Median OSATS score was 48 (IQR 41-52) points and with a
turning point at 33 procedures. POPF occurred in 39 patients
(25.5%). An OSATS score below 49, present in 77 patients
(50.3%), was associated with an increased risk of POPF, OR 4.0
2022
Sattari S A; Sattari A R; Makary M A; Hu C; He J
Laparoscopic versus open pancreatoduodenectomy in patients with periampullary tumors: A systematic review and meta-analysis Journal Article
In: Ann. Surg., 2022.
@article{Sattari2022-eg,
title = {Laparoscopic versus open pancreatoduodenectomy in patients with periampullary tumors: A systematic review and meta-analysis},
author = {Shahab Aldin Sattari and Ali Reza Sattari and Martin A Makary and Chen Hu and Jin He},
doi = {10.1097/SLA.0000000000005785},
year = {2022},
date = {2022-12-01},
urldate = {2022-12-01},
journal = {Ann. Surg.},
abstract = {OBJECTIVE: To conduct a systematic review and meta-analysis of
randomized controlled trials (RCTs) compared laparoscopic
pancreatoduodenectomy (LPD) versus open pancreatoduodenectomy
(OPD) in patients with periampullary tumors. SUMMARY BACKGROUND
DATA: LPD has gained attention; however, its safety and efficacy
versus OPD remain debatable. METHODS: We searched PubMed, and
Embase. Primary outcomes were the length of hospital stay (LOS)
(day), Clavien-Dindo grade$geq$Ⅲ complications, and 90-day
mortality. Secondary outcomes were blood loss (BL) (ml), blood
transfusion (BT), duration of operation (minute), readmission,
reoperation, comprehensive complication index (CCI) score, bile
leak, gastro- or duodenojejunostomy leak, postoperative
pancreatic fistula, postpancreatectomy hemorrhage, delayed
gastric emptying, surgical site infection (SSI), intraabdominal
infection, number of harvested lymph nodes, and R0 resection.
Pooled odds ratio (OR) or mean difference (MD) of data were
calculated using the random-effect model. The GRADE approach was
used for grading the level of evidence. RESULTS: Four RCTs
yielding 818 patients were included, of which 411 and 407
patients underwent LPD and OPD, respectively. The meta-analysis
concluded that two approaches were similar, except in the LPD group, the LOS tended to be shorter (MD=-2.54 [-5.17, 0.09},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
randomized controlled trials (RCTs) compared laparoscopic
pancreatoduodenectomy (LPD) versus open pancreatoduodenectomy
(OPD) in patients with periampullary tumors. SUMMARY BACKGROUND
DATA: LPD has gained attention; however, its safety and efficacy
versus OPD remain debatable. METHODS: We searched PubMed, and
Embase. Primary outcomes were the length of hospital stay (LOS)
(day), Clavien-Dindo grade$geq$Ⅲ complications, and 90-day
mortality. Secondary outcomes were blood loss (BL) (ml), blood
transfusion (BT), duration of operation (minute), readmission,
reoperation, comprehensive complication index (CCI) score, bile
leak, gastro- or duodenojejunostomy leak, postoperative
pancreatic fistula, postpancreatectomy hemorrhage, delayed
gastric emptying, surgical site infection (SSI), intraabdominal
infection, number of harvested lymph nodes, and R0 resection.
Pooled odds ratio (OR) or mean difference (MD) of data were
calculated using the random-effect model. The GRADE approach was
used for grading the level of evidence. RESULTS: Four RCTs
yielding 818 patients were included, of which 411 and 407
patients underwent LPD and OPD, respectively. The meta-analysis
concluded that two approaches were similar, except in the LPD group, the LOS tended to be shorter (MD=-2.54 [-5.17, 0.09
Kaslow S R; Sacks G D; Berman R S; Lee A Y; Correa-Gallego C
In: Ann. Surg., vol. Publish Ahead of Print, 2022.
@article{Kaslow2022-tl,
title = {Natural history of stage IV pancreatic cancer. Identifying survival benchmarks for curative-intent resection in patients with synchronous liver-only metastases},
author = {Sarah R Kaslow and Greg D Sacks and Russell S Berman and Ann Y Lee and Camilo Correa-Gallego},
doi = {10.1097/SLA.0000000000005753},
year = {2022},
date = {2022-11-01},
urldate = {2022-11-01},
journal = {Ann. Surg.},
volume = {Publish Ahead of Print},
publisher = {Ovid Technologies (Wolters Kluwer Health)},
abstract = {OBJECTIVE: To evaluate long-term oncologic outcomes of patients
with stage IV pancreatic ductal adenocarcinoma (PDAC) and
identify survival benchmarks for comparison when considering
resection in these patients. SUMMARY BACKGROUND DATA: Highly
selected cohorts of patients with liver-oligometastatic pancreas
cancer have reported prolonged survival following resection. The
long-term impact of surgery in this setting remains undefined
due to a lack of appropriate control groups. METHODS: We
identified patients with clinical stage IV PDAC with synchronous
liver metastases within our cancer registry. We estimated
overall survival (OS) among various patient subgroups using the
Kaplan-Meier method. To mitigate immortal time bias, we analyzed
long-term outcomes of patients who survived beyond 12 months
(landmark time) from diagnosis. RESULTS: We identified 241
patients. Median OS was 7 months (95%CI 5-9), both overall and for patients with liver-only metastasis (n=144). Ninety patients
(38% of liver-only; 40% of whole cohort) survived at least 12
months; those who received chemotherapy in this subgroup had a
median OS of 26 months (95%CI 17-39). Of these patients, those
with resectable or borderline resectable primary tumors and resectable liver-only metastasis (n=9, 4%) had a median OS of
39 months (95%CI 13-NR). CONCLUSIONS: The 4% of our cohort
that were potentially eligible for surgery experienced a
prolonged survival compared to all-comers with stage IV disease.
Oncologic outcomes of patients undergoing resection of
metastatic pancreas cancer should be assessed in the context of
the expected survival of patients potentially eligible for
surgery and not relative to all patients with stage IV disease.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
with stage IV pancreatic ductal adenocarcinoma (PDAC) and
identify survival benchmarks for comparison when considering
resection in these patients. SUMMARY BACKGROUND DATA: Highly
selected cohorts of patients with liver-oligometastatic pancreas
cancer have reported prolonged survival following resection. The
long-term impact of surgery in this setting remains undefined
due to a lack of appropriate control groups. METHODS: We
identified patients with clinical stage IV PDAC with synchronous
liver metastases within our cancer registry. We estimated
overall survival (OS) among various patient subgroups using the
Kaplan-Meier method. To mitigate immortal time bias, we analyzed
long-term outcomes of patients who survived beyond 12 months
(landmark time) from diagnosis. RESULTS: We identified 241
patients. Median OS was 7 months (95%CI 5-9), both overall and for patients with liver-only metastasis (n=144). Ninety patients
(38% of liver-only; 40% of whole cohort) survived at least 12
months; those who received chemotherapy in this subgroup had a
median OS of 26 months (95%CI 17-39). Of these patients, those
with resectable or borderline resectable primary tumors and resectable liver-only metastasis (n=9, 4%) had a median OS of
39 months (95%CI 13-NR). CONCLUSIONS: The 4% of our cohort
that were potentially eligible for surgery experienced a
prolonged survival compared to all-comers with stage IV disease.
Oncologic outcomes of patients undergoing resection of
metastatic pancreas cancer should be assessed in the context of
the expected survival of patients potentially eligible for
surgery and not relative to all patients with stage IV disease.
Takahashi S; Ohno I; Ikeda M; Konishi M; Kobayashi T; Akimoto T; Kojima M; Morinaga S; Toyama H; Shimizu Y; Miyamoto A; Tomikawa M; Takakura N; Takayama W; Hirano S; Otsubo T; Nagino M; Kimura W; Sugimachi K; Uesaka K
In: Annals of Surgery, vol. 276, no. 5, pp. E510 – E517, 2022, ISSN: 00034932, (Cited by: 15).
@article{Takahashi2022E510,
title = {Neoadjuvant S-1 With Concurrent Radiotherapy Followed by Surgery for Borderline Resectable Pancreatic Cancer: A Phase II Open-label Multicenter Prospective Trial (JASPAC05)},
author = {Shinichiro Takahashi and Izumi Ohno and Masafumi Ikeda and Masaru Konishi and Tatsushi Kobayashi and Tetsuo Akimoto and Motohiro Kojima and Soichiro Morinaga and Hirochika Toyama and Yasuhiro Shimizu and Atsushi Miyamoto and Moriaki Tomikawa and Norihisa Takakura and Wataru Takayama and Satoshi Hirano and Takehito Otsubo and Masato Nagino and Wataru Kimura and Keishi Sugimachi and Katsuhiko Uesaka},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85139571403&doi=10.1097%2fSLA.0000000000004535&partnerID=40&md5=c1aa99be218b6cfe07848d2dd18b3598},
doi = {10.1097/SLA.0000000000004535},
issn = {00034932},
year = {2022},
date = {2022-01-01},
urldate = {2022-01-01},
journal = {Annals of Surgery},
volume = {276},
number = {5},
pages = {E510 – E517},
publisher = {Wolters Kluwer Health},
abstract = {Objective: This study assessed whether neoadjuvant chemoradiotherapy (CRT) with S-1 increases the R0 resection rate in BRPC. Summary of Background Data: Although a multidisciplinary approach that includes neoadjuvant treatment has been shown to be a better strategy for BRPC than upfront resection, a standard treatment for BRPC has not been established. Methods: A multicenter, single-arm, phase II study was performed. Patients who fulfilled the criteria for BRPC received S-1 (40 mg/m2 bid) and concurrent radiotherapy (50.4 Gy in 28 fractions) before surgery. The primary endpoint was the R0 resection rate. At least 40 patients were required, with a 1-sided α = 0.05 and β = 0.05 and expected and threshold values for the primary endpoint of 30% and 10%, respectively. Results: Fifty-two patients were eligible, and 41 were confirmed to have definitive BRPC by a central review. CRT was completed in 50 (96%) patients and was well tolerated. The rate of grade 3/4 toxicity with CRT was 43%. The R0 resection rate was 52% among the 52 eligible patients and 63% among the 41 patients who were centrally confirmed to have BRPC. Postoperative grade III/IV adverse events according to the Clavien-Dindo classification were observed in 7.5%. Among the 41 centrally confirmed BRPC patients, the 2-year overall survival rate and median overall survival duration were 58% and 30.8 months, respectively. Conclusions: S-1 and concurrent radiotherapy seem to be feasible and effective at increasing the R0 resection rate and improving survival in patients with BRPC. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.},
note = {Cited by: 15},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Yamaguchi J; Yokoyama Y; Fujii T; Yamada S; Takami H; Kawashima H; Ohno E; Ishikawa T; Maeda O; Ogawa H; Kodera Y; Nagino M; Ebata T
In: Annals of Surgery, vol. 275, no. 6, pp. 1043 – 1049, 2022, ISSN: 00034932, (Cited by: 2).
@article{Yamaguchi20221043,
title = {Results of a Phase II Study on the Use of Neoadjuvant Chemotherapy (FOLFIRINOX or GEM/nab-PTX) for Borderline-resectable Pancreatic Cancer (NUPAT-01)},
author = {Junpei Yamaguchi and Yukihiro Yokoyama and Tsutomu Fujii and Suguru Yamada and Hideki Takami and Hiroki Kawashima and Eizaburo Ohno and Takuya Ishikawa and Osamu Maeda and Hiroshi Ogawa and Yasuhiro Kodera and Masato Nagino and Tomoki Ebata},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85131108074&doi=10.1097%2fSLA.0000000000005430&partnerID=40&md5=70120cfb2fbb9a0715bafde548ac56cb},
doi = {10.1097/SLA.0000000000005430},
issn = {00034932},
year = {2022},
date = {2022-01-01},
urldate = {2022-01-01},
journal = {Annals of Surgery},
volume = {275},
number = {6},
pages = {1043 – 1049},
publisher = {Lippincott Williams and Wilkins},
abstract = {Objective:Given the frequent adverse events with multidrug chemotherapy, not only the survival benefit but also the feasibility of using neoadjuvant chemotherapy to treat pancreatic cancer need to be clarified.Summary of Background Data:Although the development of multidrug chemotherapy regimens has improved the survival outcomes of patients with unresectable pancreatic cancer, the benefits of these treatments in the neo-adjuvant setting remain controversial.Methods:Patients with borderline-resectable pancreatic cancer were enrolled and randomly assigned to receive neoadjuvant chemotherapy with either FOLFIRINOX or gemcitabine with nab-paclitaxel (GEM/nab-PTX). After the completion of chemotherapy, patients underwent surgical resection when feasible. This study (NUPAT-01) was a randomized phase II trial, and the primary endpoint was the R0 resection rate.Results:Fifty-one patients were enrolled in this study [FOLFIRINOX (n = 26) and GEM/nab-PTX (n = 25)]. A total of 84.3% (n = 43/51) of the patients eventually underwent surgery, and R0 resection was achieved in 67.4% (n = 33/ 51) of the patients. Adverse events (grade >3) due to neoadjuvant treatment were observed in 45.1% of the patients (n = 23/51), and major surgical complications occurred in 30.0% (n = 13/43), with no mortality noted. The intention-to-treat analysis showed that the 3-year overall survival rate was 54.7%, with a median survival time of 39.4 months, and a significant difference in overall survival was not observed between the FOLFIRINOX and GEM/nab-PTX groups.Conclusions:These results indicate that neoadjuvant chemotherapy with FOLFIRINOX or GEM/nab-PTX is feasible and well tolerated, achieving an R0 resection rate of 67.4%. The survival of patients was even found to be favorable in the intention-to-treat analysis. © 2022 Lippincott Williams and Wilkins. All rights reserved.},
note = {Cited by: 2},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Ghaneh P; Palmer D; Cicconi S; Jackson R; Halloran C M; Rawcliffe C; Sripadam R; Mukherjee S; Soonawalla Z; Wadsley J; Al-Mukhtar A; Dickson E; Graham J; Jiao L; Wasan H S; Tait I S; Prachalias A; Ross P; Valle J W; O'Reilly D A; Al-Sarireh B; Gwynne S; Ahmed I; Connolly K; Yim K; Cunningham D; Armstrong T; Archer C; Roberts K; Ma Y T; Springfeld C; Tjaden C; Hackert T; Büchler M W; Neoptolemos J P
In: The Lancet Gastroenterology & Hepatology, 2022, ISSN: 2468-1253.
@article{GHANEH2022,
title = {Immediate surgery compared with short-course neoadjuvant gemcitabine plus capecitabine, FOLFIRINOX, or chemoradiotherapy in patients with borderline resectable pancreatic cancer (ESPAC5): a four-arm, multicentre, randomised, phase 2 trial},
author = {Paula Ghaneh and Daniel Palmer and Silvia Cicconi and Richard Jackson and Christopher Michael Halloran and Charlotte Rawcliffe and Rajaram Sripadam and Somnath Mukherjee and Zahir Soonawalla and Jonathan Wadsley and Ahmed Al-Mukhtar and Euan Dickson and Janet Graham and Long Jiao and Harpreet S Wasan and Iain S Tait and Andreas Prachalias and Paul Ross and Juan W Valle and Derek A O'Reilly and Bilal Al-Sarireh and Sarah Gwynne and Irfan Ahmed and Kate Connolly and Kein-Long Yim and David Cunningham and Thomas Armstrong and Caroline Archer and Keith Roberts and Yuk Ting Ma and Christoph Springfeld and Christine Tjaden and Thilo Hackert and Markus W Büchler and John P Neoptolemos},
url = {https://www.sciencedirect.com/science/article/pii/S246812532200348X},
doi = {https://doi.org/10.1016/S2468-1253(22)00348-X},
issn = {2468-1253},
year = {2022},
date = {2022-01-01},
urldate = {2022-01-01},
journal = {The Lancet Gastroenterology & Hepatology},
abstract = {Summary
Background
Patients with borderline resectable pancreatic ductal adenocarcinoma have relatively low resection rates and poor survival despite the use of adjuvant chemotherapy. The aim of our study was to establish the feasibility and efficacy of three different types of short-course neoadjuvant therapy compared with immediate surgery.
Methods
ESPAC5 (formerly known as ESPAC-5f) was a multicentre, open label, randomised controlled trial done in 16 pancreatic centres in two countries (UK and Germany). Eligible patients were aged 18 years or older, with a WHO performance status of 0 or 1, biopsy proven pancreatic ductal adenocarcinoma in the pancreatic head, and were staged as having a borderline resectable tumour by contrast-enhanced CT criteria following central review. Participants were randomly assigned by means of minimisation to one of four groups: immediate surgery; neoadjuvant gemcitabine and capecitabine (gemcitabine 1000 mg/m2 on days 1, 8, and 15, and oral capecitabine 830 mg/m2 twice a day on days 1–21 of a 28-day cycle for two cycles); neoadjuvant FOLFIRINOX (oxaliplatin 85 mg/m2, irinotecan 180 mg/m2, folinic acid given according to local practice, and fluorouracil 400 mg/m2 bolus injection on days 1 and 15 followed by 2400 mg/m2 46 h intravenous infusion given on days 1 and 15, repeated every 2 weeks for four cycles); or neoadjuvant capecitabine-based chemoradiation (total dose 50·4 Gy in 28 daily fractions over 5·5 weeks [1·8 Gy per fraction, Monday to Friday] with capecitabine 830 mg/m2 twice daily [Monday to Friday] throughout radiotherapy). Patients underwent restaging contrast-enhanced CT at 4–6 weeks after neoadjuvant therapy and underwent surgical exploration if the tumour was still at least borderline resectable. All patients who had their tumour resected received adjuvant therapy at the oncologist's discretion. Primary endpoints were recruitment rate and resection rate. Analyses were done on an intention-to-treat basis. This trial is registered with ISRCTN, 89500674, and is complete.
Findings Between Sept 3, 2014, and Dec 20, 2018, from 478 patients screened, 90 were randomly assigned to a group (33 to immediate surgery, 20 to gemcitabine plus capecitabine, 20 to FOLFIRINOX, and 17 to capecitabine-based chemoradiation); four patients were excluded from the intention-to-treat analysis (one in the capecitabine-based chemoradiotherapy withdrew consent before starting therapy and three [two in the immediate surgery group and one in the gemcitabine plus capecitabine group] were found to be ineligible after randomisation). 44 (80%) of 55 patients completed neoadjuvant therapy. The recruitment rate was 25·92 patients per year from 16 sites; 21 (68%) of 31 patients in the immediate surgery and 30 (55%) of 55 patients in the combined neoadjuvant therapy groups underwent resection (p=0·33). R0 resection was achieved in three (14%) of 21 patients in the immediate surgery group and seven (23%) of 30 in the neoadjuvant therapy groups combined (p=0·49). Surgical complications were observed in 29 (43%) of 68 patients who underwent surgery; no patients died within 30 days. 46 (84%) of 55 patients receiving neoadjuvant therapy were available for restaging. Six (13%) of 46 had a partial response. Median follow-up time was 12·2 months (95% CI 12·0–12·4). 1-year overall survival was 39% (95% CI 24–61) for immediate surgery, 78% (60–100) for gemcitabine plus capecitabine, 84% (70–100) for FOLFIRINOX, and 60% (37–97) for capecitabine-based chemoradiotherapy (p=0·0028). 1-year disease-free survival from surgery was 33% (95% CI 19–58) for immediate surgery and 59% (46–74) for the combined neoadjuvant therapies (hazard ratio 0·53 [95% CI 0·28–0·98]},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background
Patients with borderline resectable pancreatic ductal adenocarcinoma have relatively low resection rates and poor survival despite the use of adjuvant chemotherapy. The aim of our study was to establish the feasibility and efficacy of three different types of short-course neoadjuvant therapy compared with immediate surgery.
Methods
ESPAC5 (formerly known as ESPAC-5f) was a multicentre, open label, randomised controlled trial done in 16 pancreatic centres in two countries (UK and Germany). Eligible patients were aged 18 years or older, with a WHO performance status of 0 or 1, biopsy proven pancreatic ductal adenocarcinoma in the pancreatic head, and were staged as having a borderline resectable tumour by contrast-enhanced CT criteria following central review. Participants were randomly assigned by means of minimisation to one of four groups: immediate surgery; neoadjuvant gemcitabine and capecitabine (gemcitabine 1000 mg/m2 on days 1, 8, and 15, and oral capecitabine 830 mg/m2 twice a day on days 1–21 of a 28-day cycle for two cycles); neoadjuvant FOLFIRINOX (oxaliplatin 85 mg/m2, irinotecan 180 mg/m2, folinic acid given according to local practice, and fluorouracil 400 mg/m2 bolus injection on days 1 and 15 followed by 2400 mg/m2 46 h intravenous infusion given on days 1 and 15, repeated every 2 weeks for four cycles); or neoadjuvant capecitabine-based chemoradiation (total dose 50·4 Gy in 28 daily fractions over 5·5 weeks [1·8 Gy per fraction, Monday to Friday] with capecitabine 830 mg/m2 twice daily [Monday to Friday] throughout radiotherapy). Patients underwent restaging contrast-enhanced CT at 4–6 weeks after neoadjuvant therapy and underwent surgical exploration if the tumour was still at least borderline resectable. All patients who had their tumour resected received adjuvant therapy at the oncologist's discretion. Primary endpoints were recruitment rate and resection rate. Analyses were done on an intention-to-treat basis. This trial is registered with ISRCTN, 89500674, and is complete.
Findings Between Sept 3, 2014, and Dec 20, 2018, from 478 patients screened, 90 were randomly assigned to a group (33 to immediate surgery, 20 to gemcitabine plus capecitabine, 20 to FOLFIRINOX, and 17 to capecitabine-based chemoradiation); four patients were excluded from the intention-to-treat analysis (one in the capecitabine-based chemoradiotherapy withdrew consent before starting therapy and three [two in the immediate surgery group and one in the gemcitabine plus capecitabine group] were found to be ineligible after randomisation). 44 (80%) of 55 patients completed neoadjuvant therapy. The recruitment rate was 25·92 patients per year from 16 sites; 21 (68%) of 31 patients in the immediate surgery and 30 (55%) of 55 patients in the combined neoadjuvant therapy groups underwent resection (p=0·33). R0 resection was achieved in three (14%) of 21 patients in the immediate surgery group and seven (23%) of 30 in the neoadjuvant therapy groups combined (p=0·49). Surgical complications were observed in 29 (43%) of 68 patients who underwent surgery; no patients died within 30 days. 46 (84%) of 55 patients receiving neoadjuvant therapy were available for restaging. Six (13%) of 46 had a partial response. Median follow-up time was 12·2 months (95% CI 12·0–12·4). 1-year overall survival was 39% (95% CI 24–61) for immediate surgery, 78% (60–100) for gemcitabine plus capecitabine, 84% (70–100) for FOLFIRINOX, and 60% (37–97) for capecitabine-based chemoradiotherapy (p=0·0028). 1-year disease-free survival from surgery was 33% (95% CI 19–58) for immediate surgery and 59% (46–74) for the combined neoadjuvant therapies (hazard ratio 0·53 [95% CI 0·28–0·98]
Ban D; Tanabe M
Artery-First Approach in Pancreaticoduodenectomy Book Chapter
In: Makuuchi, Masatoshi; Kokudo, Norihiro; Popescu, Irinel; Belghiti, Jacques; Han, Ho-Seong; Takaori, Kyoichi; Duda, Dan G. (Ed.): The IASGO Textbook of Multi-Disciplinary Management of Hepato-Pancreato-Biliary Diseases, pp. 289–295, Springer Nature Singapore, Singapore, 2022, ISBN: 978-981-19-0063-1.
@inbook{Ban2022,
title = {Artery-First Approach in Pancreaticoduodenectomy},
author = {Daisuke Ban and Minoru Tanabe},
editor = {Masatoshi Makuuchi and Norihiro Kokudo and Irinel Popescu and Jacques Belghiti and Ho-Seong Han and Kyoichi Takaori and Dan G. Duda},
url = {https://doi.org/10.1007/978-981-19-0063-1_37},
doi = {10.1007/978-981-19-0063-1_37},
isbn = {978-981-19-0063-1},
year = {2022},
date = {2022-01-01},
urldate = {2022-01-01},
booktitle = {The IASGO Textbook of Multi-Disciplinary Management of Hepato-Pancreato-Biliary Diseases},
pages = {289--295},
publisher = {Springer Nature Singapore},
address = {Singapore},
abstract = {Due to its anatomical characteristics, cancer of the pancreatic head often invades the superior mesenteric vein (SMV), the portal vein (PV), and the plexus surrounding the superior mesenteric artery (SMA). Several different approaches to pancreaticoduodenectomy (PD) have been proposed in order to achieve R0 resection.},
keywords = {},
pubstate = {published},
tppubtype = {inbook}
}
Nakao A
Isolated Pancreatoduodenectomy with Portal Vein Resection Using the Nakao Mesenteric Approach Book Chapter
In: Makuuchi, Masatoshi; Kokudo, Norihiro; Popescu, Irinel; Belghiti, Jacques; Han, Ho-Seong; Takaori, Kyoichi; Duda, Dan G. (Ed.): The IASGO Textbook of Multi-Disciplinary Management of Hepato-Pancreato-Biliary Diseases, pp. 307–312, Springer Nature Singapore, Singapore, 2022, ISBN: 978-981-19-0063-1.
@inbook{Nakao2022,
title = {Isolated Pancreatoduodenectomy with Portal Vein Resection Using the Nakao Mesenteric Approach},
author = {Akimasa Nakao},
editor = {Masatoshi Makuuchi and Norihiro Kokudo and Irinel Popescu and Jacques Belghiti and Ho-Seong Han and Kyoichi Takaori and Dan G. Duda},
url = {https://doi.org/10.1007/978-981-19-0063-1_39},
doi = {10.1007/978-981-19-0063-1_39},
isbn = {978-981-19-0063-1},
year = {2022},
date = {2022-01-01},
urldate = {2022-01-01},
booktitle = {The IASGO Textbook of Multi-Disciplinary Management of Hepato-Pancreato-Biliary Diseases},
pages = {307--312},
publisher = {Springer Nature Singapore},
address = {Singapore},
abstract = {The ideal surgical approach for pancreatic head cancer is isolated pancreatoduodenectomy (PD); that is, en bloc resection using non-touch isolation technique. However, this approach is difficult because of the complex peripancreatic vascular anatomy. In 1981, we developed an antithrombogenic bypass catheter for the portal vein (PV) to prevent portal congestion or hepatic ischemia during PV resection and facilitate simultaneous resection of the hepatic artery. In 1992, we developed a mesenteric approach for PD. The mesenteric approach allows dissection from the non-cancer infiltrating side and determination of cancer-free surgical margins and resectability, followed by systematic lymphadenectomy around the superior mesenteric artery. This approach enables early ligation of the inferior pancreatoduodenal artery and excision of the second portion of pancreatic head nerve plexus. Through this development of the mesenteric approach and antithrombogenic catheter-bypass procedure of the PV, establishment of isolated PD was completed in 1992. This is the ideal surgery for pancreatic head cancer from both surgical and oncological viewpoints. The precise surgical techniques of isolated PD, using the Nakao mesenteric approach are herein introduced.},
keywords = {},
pubstate = {published},
tppubtype = {inbook}
}
Oba A; Kato T; Chiaro M D; Wu Y H A; Inoue Y; Takahashi Y
Pancreaticoduodenectomy with Hepatic Artery Resection Book Chapter
In: Makuuchi, Masatoshi; Kokudo, Norihiro; Popescu, Irinel; Belghiti, Jacques; Han, Ho-Seong; Takaori, Kyoichi; Duda, Dan G. (Ed.): The IASGO Textbook of Multi-Disciplinary Management of Hepato-Pancreato-Biliary Diseases, pp. 313–318, Springer Nature Singapore, Singapore, 2022, ISBN: 978-981-19-0063-1.
@inbook{Oba2022,
title = {Pancreaticoduodenectomy with Hepatic Artery Resection},
author = {Atsushi Oba and Tomotaka Kato and Marco Del Chiaro and Y. H. Andrew Wu and Yosuke Inoue and Yu Takahashi},
editor = {Masatoshi Makuuchi and Norihiro Kokudo and Irinel Popescu and Jacques Belghiti and Ho-Seong Han and Kyoichi Takaori and Dan G. Duda},
url = {https://doi.org/10.1007/978-981-19-0063-1_40},
doi = {10.1007/978-981-19-0063-1_40},
isbn = {978-981-19-0063-1},
year = {2022},
date = {2022-01-01},
urldate = {2022-01-01},
booktitle = {The IASGO Textbook of Multi-Disciplinary Management of Hepato-Pancreato-Biliary Diseases},
pages = {313--318},
publisher = {Springer Nature Singapore},
address = {Singapore},
abstract = {With the development of novel and effective multidrug chemotherapy, several pancreatic centers have reported that the combination of preoperative chemotherapy and arterial resection can provide a favorable long-term prognosis for T4-stage (i.e., major artery infiltration) pancreatic cancer (PC) patients. A recent nomogram formulated to predict the post-resection prognosis of PC found that neoadjuvant treatment was an independent prognostic factor, whereas T4 stage was not a factor of poor prognosis. This implies that systemic control is the most important factor for improving the prognosis of PC and local progression has less impact on the prognosis in the era of useful multidrug regimens. However, even if favorable control of PC is achieved with neoadjuvant chemotherapy, pancreatectomy with hepatic artery (HA) resection is technically challenging. This approach requires a high expertise that is characterized with detailed preoperative image preparation, planning several options of HA reconstruction, meticulous intraoperative resection, and appropriate postoperative management. This chapter examines the innovative surgical approach and management in the pancreaticoduodenectomy with HA resection and reconstruction.},
keywords = {},
pubstate = {published},
tppubtype = {inbook}
}
Bachellier P; Addeo P
Pancreaticoduodenectomy with Superior Mesenteric Resection and Reconstruction for Locally Advanced Tumors Book Chapter
In: Makuuchi, Masatoshi; Kokudo, Norihiro; Popescu, Irinel; Belghiti, Jacques; Han, Ho-Seong; Takaori, Kyoichi; Duda, Dan G. (Ed.): The IASGO Textbook of Multi-Disciplinary Management of Hepato-Pancreato-Biliary Diseases, pp. 327–333, Springer Nature Singapore, Singapore, 2022, ISBN: 978-981-19-0063-1.
@inbook{Bachellier2022,
title = {Pancreaticoduodenectomy with Superior Mesenteric Resection and Reconstruction for Locally Advanced Tumors},
author = {Philippe Bachellier and Pietro Addeo},
editor = {Masatoshi Makuuchi and Norihiro Kokudo and Irinel Popescu and Jacques Belghiti and Ho-Seong Han and Kyoichi Takaori and Dan G. Duda},
url = {https://doi.org/10.1007/978-981-19-0063-1_42},
doi = {10.1007/978-981-19-0063-1_42},
isbn = {978-981-19-0063-1},
year = {2022},
date = {2022-01-01},
urldate = {2022-01-01},
booktitle = {The IASGO Textbook of Multi-Disciplinary Management of Hepato-Pancreato-Biliary Diseases},
pages = {327--333},
publisher = {Springer Nature Singapore},
address = {Singapore},
abstract = {Pancreatectomies with arterial resections were initially characterized by high postoperative mortality and poor long-term survival as reported by Fortner et al. and then abandoned. The introduction of new efficacious chemotherapy regimens (FOLFIRINOX) along with the extensive experience in venous resection for borderline pancreatic tumors has brought renewed interest in extended pancreatic resection for locally advanced malignancy. The experience needed for performing such complex resections goes beyond pancreatic surgery alone and entails skills in vascular surgery. Reconstructing arterial vessels might need autologous and/or heterologous vascular substitutes which should be available immediately and accurate preoperative planning and simulation on the basis of cross-sectional imaging should be the rule. Resection of the superior mesenteric artery could be seen as one of the most challenging arterial resection at the time of pancreatectomy because of: (1) the frequent presence of an associated venous invasion; (2) the variable degree of tumoral infiltration downward through the mesentery; (3) the necessity of a mesenteric approach and complete mesenteric dissection; (4) the need for reconstructing several jejunal and ileal branches; (5) the high mortality rates (20%) reported so far. In this chapter we will describe step-by-step the surgical technique of our standardized approach for superior mesenteric artery resection during pancreaticoduodenectomy.},
keywords = {},
pubstate = {published},
tppubtype = {inbook}
}
Marino M V; Ramera M; Esposito A
Robotic Distal Pancreatectomy Book Chapter
In: Makuuchi, Masatoshi; Kokudo, Norihiro; Popescu, Irinel; Belghiti, Jacques; Han, Ho-Seong; Takaori, Kyoichi; Duda, Dan G. (Ed.): The IASGO Textbook of Multi-Disciplinary Management of Hepato-Pancreato-Biliary Diseases, pp. 373–376, Springer Nature Singapore, Singapore, 2022, ISBN: 978-981-19-0063-1.
@inbook{Marino2022,
title = {Robotic Distal Pancreatectomy},
author = {Marco Vito Marino and Marco Ramera and Alessandro Esposito},
editor = {Masatoshi Makuuchi and Norihiro Kokudo and Irinel Popescu and Jacques Belghiti and Ho-Seong Han and Kyoichi Takaori and Dan G. Duda},
url = {https://doi.org/10.1007/978-981-19-0063-1_49},
doi = {10.1007/978-981-19-0063-1_49},
isbn = {978-981-19-0063-1},
year = {2022},
date = {2022-01-01},
urldate = {2022-01-01},
booktitle = {The IASGO Textbook of Multi-Disciplinary Management of Hepato-Pancreato-Biliary Diseases},
pages = {373--376},
publisher = {Springer Nature Singapore},
address = {Singapore},
abstract = {Since its first description in 1994 by Cuschieri (J R Coll Surg Edinb 39:178--84, 1994), laparoscopic left pancreatectomy has been increasingly performed by hepato-pancreato-biliary surgeons worldwide. Despite reported benefits of less blood loss, faster recovery and shorter hospital stay over the classic open procedure (de Rooij et al. Ann Surg 269(1):2--9, 2019; Bjornsson et al. Br J Surg 2020), the first International Survey on Minimally Invasive Pancreatic Resection reported the minimally invasive distal pancreatectomy median lifetime case volume was quite low even for expert pancreatic surgeons (van Hilst et al. HPB (Oxford) 19:190--204, 2017). The technical expertise required for tissue manipulation, vascular dissection and control of bleeding while ensuring adequate oncological outcome remains a significant hindrance to widespread adoption. The lack of specific training program, the poor ergonomics definitively limited the widespread of the laparoscopic distal pancreatectomy. The da Vinci robotic system (Intuitive Surgical, Sunnyvale, CA, USA) with its microsuturing and microdissection capabilities associated to an enhanced visualization may potentially provide several advantages over the laparoscopic approach. Early reports show encouraging results over the laparoscopic distal pancreatectomy in terms of reduced blood loss (Chen et al. Surg Endosc 29:3507--18, 2015), increased splenic preservation rate (Hong et al. Surg Endosc 34:2465--2473, 2020), reduced conversion to open with comparable short term oncological efficacy (Marino et al. Dig Surg 37:229--239, 2020). There is a lack to technical standardization of approach and patient selection via novel difficulty scoring needs to be validated in larger cohorts. The prevention of clinically significant pancreatic fistula continues to be a challenge and long term oncological outcomes for malignancy remains unclear. Limitations of cost and learning curve especially with the adoption of more complex procedures will need to be overcome for wider application of the robotic approach.},
keywords = {},
pubstate = {published},
tppubtype = {inbook}
}
2021
di Oncologia Medica (AIOM) A I
Linee guida Carcinoma del Pancreas Esocrino Working paper
2021.
@workingpaper{nokey,
title = {Linee guida Carcinoma del Pancreas Esocrino},
author = {Associazione Italiana di Oncologia Medica (AIOM)},
url = {https://snlg.iss.it/wp-content/uploads/2021/10/LG_270_ca_pancreas_agg2021.pdf},
year = {2021},
date = {2021-10-04},
urldate = {2021-10-04},
keywords = {},
pubstate = {published},
tppubtype = {workingpaper}
}
- Ultimo aggiornamento della pagina: 23/03/2023