@article{Kodali2025815,

title = {The 2024 ILTS-ILCA consensus recommendations for liver transplantation for HCC and intrahepatic cholangiocarcinoma},

author = {Sudha Kodali and Laura Kulik and Antonio D'Allessio and Eleonora De Martin and Abdul Rahman Hakeem and Monica Lewinska and Stacie Lindsey and Ken Liu and Zorana Maravic and Madhukar S. Patel and David Pinato and Ashwin Rammohan and Nicole Rich and Marco Sanduzzi Zamparelli and David W. Victor and Carmen Vinaxia and Elizabeth W. Brombosz and Augusto Villanueva and Tim Meyer and Nazia Selzner and Rafik Mark Ghobrial and Mohamed Rela and Gonzalo Sapisochin and Maen Abdelrahim and Vatche Agopian and Deniz Balci and Jordi Bruix and Tanios S. Bekaii-Saab and Marina Berenguer and Prashant Bhangui and Sherrie Bhoori and Albert Chi Yan Chan and Stephen L. Chan and Alfred Kow Wei Chieh and Francois Durand and Bijan Eghtesad and Ahmed Elsabbagh and Karim J. Halazun and Milind Javle and Taizo Hibi and Dong-Hwan Jung and Korosh Khalili and Jeong Min Lee and Robert Lewandowski and Pal Dag Line and Josep Maria Llovet and Vincenzo Mazzaferro and Valeria Mas and Neil Mehta and Helen Morement and Grainne O'Kane and Valerie Paradis and Neehar Parikh and Anjana Pillai and Wojtek Polak and James Pomposelli and Lorenza Rimassa and Amit Singal and Arvinder Singh Soin and Parissa Tabrizian and Christian Toso and Juan Valle and Eric Vibert and Arndt Vogel and Jessica Zucman Rossi and Kymberly Watt and Andrea Wilson Woods},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-86000331526&doi=10.1097%2fLVT.0000000000000589&partnerID=40&md5=10e3036c9ee0a41c6b66ff876d53ca2c},

doi = {10.1097/LVT.0000000000000589},

issn = {15276465},

year  = {2025},

date = {2025-01-01},

urldate = {2025-01-01},

journal = {Liver Transplantation},

volume = {31},

number = {6},

pages = {815 – 831},

publisher = {Lippincott Williams and Wilkins},

abstract = {Liver transplantation (LT) provides the best long-term survival outcomes for patients with liver cancer. As a result, the field of transplant oncology has grown greatly over the past few decades, and many centers have expanded their criteria to allow increased access to LT for liver malignancies. Center-level guidelines and practices in transplant oncology significantly vary across the world, leading to debate regarding the best course of treatment for this patient population. An international consensus conference was convened by the International Liver Transplantation Society and the International Liver Cancer Association on February 1-2, 2024, in Valencia, Spain to establish a more universal consensus regarding LT for oncologic indications. The conference followed the Delphi process, followed by an external expert review. Consensus statements were accepted regarding patient assessment and waitlisting criteria, pretransplant treatment (including immunotherapy) and downstaging, living donor LT, post-LT patient management, and patient-and caregiver-related outcomes. The multidisciplinary participants in the consensus conference provided up-to-date recommendations regarding the selection and management of patients with liver cancer being considered for LT. Although participants deferred to center protocols in many cases, there was great interest in safely expanding access to LT for patients with larger tumor burden and biologically amenable lesions. Copyright © 2025 American Association for the Study of Liver Diseases.},

note = {Cited by: 5},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Roth2024,

title = {Biliary tract cancers: French national clinical practice guidelines for diagnosis, treatments and follow-up (TNCD, SNFGE, FFCD, UNICANCER, GERCOR, SFCD, SFED, AFEF, SFRO, SFP, SFR, ACABi, ACHBPT)},

author = {Gael S. Roth and Loic Verlingue and Matthieu Sarabi and Jean-Frédéric Blanc and Emmanuel Boleslawski and Karim Boudjema and Anne-Laure Bretagne-Bignon and Marine Camus-Duboc and Romain Coriat and Gilles Créhange and Thierry De Baere and Christelle Fouchardière and Clarisse Dromain and Julien Edeline and Maximiliano Gelli and Boris Guiu and Samy Horn and Valérie Laurent-Croise and Côme Lepage and Astrid Lièvre and Anthony Lopez and Sylvain Manfredi and Julie Meilleroux and Cindy Neuzillet and Valérie Paradis and Frédéric Prat and Maxime Ronot and Olivier Rosmorduc and Antonio Sa Cunha and Olivier Soubrane and Anthony Turpin and Christophe Louvet and Olivier Bouché and David Malka},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85188118767&doi=10.1016%2fj.ejca.2024.114000&partnerID=40&md5=e2942737317c09600207cac08af2a0ad},

doi = {10.1016/j.ejca.2024.114000},

issn = {09598049},

year  = {2024},

date = {2024-01-01},

urldate = {2024-01-01},

journal = {European Journal of Cancer},

volume = {202},

publisher = {Elsevier Ltd},

abstract = {Introduction: This document is a summary of the French intergroup guidelines of the management of biliary tract cancers (BTC) (intrahepatic, perihilar and distal cholangiocarcinomas, and gallbladder carcinomas) published in September 2023, available on the website of the French Society of Gastroenterology (SNFGE) (www.tncd.org). Methods: This collaborative work was conducted under the auspices of French medical and surgical societies involved in the management of BTC. Recommendations were graded in three categories (A, B and C) according to the level of scientific evidence until August 2023. Results: BTC diagnosis and staging is mainly based on enhanced computed tomography, magnetic resonance imaging and (endoscopic) ultrasound-guided biopsy. Treatment strategy depends on BTC subtype and disease stage. Surgery followed by adjuvant capecitabine is recommended for localised disease. No neoadjuvant treatment is validated to date. Cisplatin-gemcitabine chemotherapy combined to the anti-PD-L1 inhibitor durvalumab is the first-line standard of care for advanced disease. Early systematic tumour molecular profiling is recommended to screen for actionable alterations (IDH1 mutations, FGFR2 rearrangements, HER2 amplification, BRAFV600E mutation, MSI/dMMR status, etc.) and guide subsequent lines of treatment. In the absence of actionable alterations, FOLFOX chemotherapy is the only second-line standard-of-care. No third-line chemotherapy standard is validated to date. Conclusion: These guidelines are intended to provide a personalised therapeutic strategy for daily clinical practice. Each individual BTC case should be discussed by a multidisciplinary team. © 2024 Elsevier Ltd},

note = {Cited by: 7},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Rushbrook2023-pd,

title = {British Society of Gastroenterology guidelines for the diagnosis  and management of cholangiocarcinoma},

author = {Simon M Rushbrook and Timothy James Kendall and Yoh Zen and Raneem Albazaz and Prakash Manoharan and Stephen P Pereira and Richard Sturgess and Brian R Davidson and Hassan Z Malik and Derek Manas and Nigel Heaton and K Raj Prasad and John Bridgewater and Juan W Valle and Rebecca Goody and Maria Hawkins and Wendy Prentice and Helen Morement and Martine Walmsley and Shahid A Khan},

url = {https://gut.bmj.com/content/early/2023/09/27/gutjnl-2023-330029

https://gut.bmj.com/content/gutjnl/early/2023/09/27/gutjnl-2023-330029.full.pdf},

doi = {10.1136/gutjnl-2023-330029},

year  = {2023},

date = {2023-09-01},

urldate = {2023-09-01},

journal = {Gut},

pages = {gutjnl–2023–330029},

publisher = {BMJ},

abstract = {These guidelines for the diagnosis and management of 

 cholangiocarcinoma (CCA) were commissioned by the British 

 Society of Gastroenterology liver section. The guideline writing 

 committee included a multidisciplinary team of experts from 

 various specialties involved in the management of CCA, as well 

 as patient/public representatives from AMMF (the 

 Cholangiocarcinoma Charity) and PSC Support. Quality of evidence 

 is presented using the Appraisal of Guidelines for Research and 

 Evaluation (AGREE II) format. The recommendations arising are to 

 be used as guidance rather than as a strict protocol-based 

 reference, as the management of patients with CCA is often 

 complex and always requires individual patient-centred 

 considerations.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{European_Association_for_the_Study_of_the_Liver_Electronic_address_easlofficeeaslofficeeu2023-gz,

title = {EASL-ILCA clinical practice guidelines on intrahepatic  cholangiocarcinoma},

author = {European Association easloffice@easloffice.eu and European Association Liver},

url = {https://www.journal-of-hepatology.eu/article/S0168-8278(23)00185-X/fulltext

https://www.journal-of-hepatology.eu/action/showPdf?pii=S0168-8278%2823%2900185-X

},

doi = {10.1016/j.jhep.2023.03.010},

year  = {2023},

date = {2023-03-01},

urldate = {2023-03-01},

journal = {J. Hepatol.},

abstract = {Intrahepatic cholangiocarcinoma (iCCA) emerges inside the liver 

 from bile ductules to the second-order bile ducts, represents the 

 second most frequent primary liver cancer besides hepatocellular 

 carcinoma and, unfortunately, is globally increasing in term of 

 incidence. The silent presentation, late diagnosis, the highly 

 aggressive nature and resistance to treatments lead to alarming 

 mortality. Early diagnosis, molecular characterization, accurate 

 staging and personalized multidisciplinary treatments represent 

 challenges for researchers and physicians. Unfortunately, these 

 challenges are beset by the high heterogeneity of iCCA at the 

 clinical, genomic, epigenetic and molecular levels that very 

 often preclude successful management. Nonetheless, in the last 

 few years, progress has been achieved in molecular 

 characterization, surgical management and targeted therapies. The 

 recent advance together with the awareness that iCCA represents a 

 distinct entity amongst the CCA family, led the ILCA and EASL 

 governing boards to commission and charge international experts 

 to draft dedicated guidelines to aid physicians towards an 

 evidence-based approach for the diagnostic, prognostic, and 

 therapeutic management of iCCA.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid36083140,

title = {AASLD Practice Guidance on Primary Sclerosing Cholangitis and Cholangiocarcinoma},

author = {Christopher L Bowlus and Lionel Arrivé and Annika Bergquist and Mark Deneau and Lisa Forman and Sumera I Ilyas and Keri E Lunsford and Mercedes Martinez and Gonzalo Sapisochin and Rachna Shroff and James H Tabibian and David N Assis},

doi = {10.1002/hep.32771},

issn = {1527-3350},

year  = {2022},

date = {2022-09-01},

urldate = {2022-09-01},

journal = {Hepatology},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Kubo2022290,

title = {Liver Cancer Study Group of Japan Clinical Practice Guidelines for Intrahepatic Cholangiocarcinoma},

author = {Shoji Kubo and Hiroji Shinkawa and Yoshinari Asaoka and Tatsuya Ioka and Hiroshi Igaki and Namiki Izumi and Takao Itoi and Michiaki Unno and Masayuki Ohtsuka and Takuji Okusaka and Masumi Kadoya and Masatoshi Kudo and Takashi Kumada and Norihiro Kokudo and Michiie Sakamoto and Yoshihiro Sakamoto and Hideyuki Sakurai and Tadatoshi Takayama and Osamu Nakashima and Yasushi Nagata and Etsuro Hatano and Kenichi Harada and Takamichi Murakami and Masakazu Yamamoto},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85134222582&doi=10.1159%2f000522403&partnerID=40&md5=85a60f3437ed401dcf4b7154c820b351},

doi = {10.1159/000522403},

issn = {22351795},

year  = {2022},

date = {2022-01-01},

urldate = {2022-01-01},

journal = {Liver Cancer},

volume = {11},

number = {4},

pages = {290 – 314},

publisher = {S. Karger AG},

abstract = {This paper presents the first version of clinical practice guidelines for intrahepatic cholangiocarcinoma (ICC) established by the Liver Cancer Study Group of Japan. These guidelines consist of 1 treatment algorithm, 5 background statements, 16 clinical questions, and 1 clinical topic, including etiology, staging, pathology, diagnosis, and treatments. Globally, a high incidence of ICC has been reported in East and Southeast Asian countries, and the incidence has been gradually increasing in Japan and also in Western countries. Reported risk factors for ICC include cirrhosis, hepatitis B/C, alcohol consumption, diabetes, obesity, smoking, nonalcoholic steatohepatitis, and liver fluke infestation, as well as biliary diseases, such as primary sclerosing cholangitis, hepatolithiasis, congenital cholangiectasis, and Caroli disease. Chemical risk factors include thorium-232, 1,2-dichloropropane, and dichloromethane. CA19-9 and CEA are recommended as tumor markers for early detection and diagnostic of ICC. Abdominal ultrasonography, CT, and MRI are effective imaging modalities for diagnosing ICC. If bile duct invasion is suspected, imaging modalities for examining the bile ducts may be useful. In unresectable cases, tumor biopsy should be considered when deemed necessary for the differential diagnosis and drug therapy selection. The mainstay of treatment for patients with Child-Pugh class A or B liver function is surgical resection and drug therapy. If the patient has no regional lymph node metastasis (LNM) and has a single tumor, resection is the treatment of choice. If both regional LNM and multiple tumors are present, drug therapy is the first treatment of choice. If the patient has either regional LNM or multiple tumors, resection or drug therapy is selected, depending on the extent of metastasis or the number of tumors. If distant metastasis is present, drug therapy is the treatment of choice. Percutaneous ablation therapy may be considered for patients who are ineligible for surgical resection or drug therapy due to decreased hepatic functional reserve or comorbidities. For unresectable ICC without extrahepatic metastasis, stereotactic radiotherapy (tumor size ≤5 cm) or particle radiotherapy (no size restriction) may be considered. ICC is generally not indicated for liver transplantation, and palliative care is recommended for patients with Child-Pugh class C liver function. © 2022 The Author(s).},

note = {Cited by: 0; All Open Access, Gold Open Access, Green Open Access},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Nagino202126,

title = {Clinical practice guidelines for the management of biliary tract cancers 2019: The 3rd English edition},

author = {Masato Nagino and Satoshi Hirano and Hideyuki Yoshitomi and Taku Aoki and Katsuhiko Uesaka and Michiaki Unno and Tomoki Ebata and Masaru Konishi and Keiji Sano and Kazuaki Shimada and Hiroaki Shimizu and Ryota Higuchi and Toshifumi Wakai and Hiroyuki Isayama and Takuji Okusaka and Toshio Tsuyuguchi and Yoshiki Hirooka and Junji Furuse and Hiroyuki Maguchi and Kojiro Suzuki and Hideya Yamazaki and Hiroshi Kijima and Akio Yanagisawa and Masahiro Yoshida and Yukihiro Yokoyama and Takashi Mizuno and Itaru Endo},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85098000027&doi=10.1002%2fjhbp.870&partnerID=40&md5=e2f525f8a8276af922fc928beb153725},

doi = {10.1002/jhbp.870},

issn = {18686974},

year  = {2021},

date = {2021-01-01},

urldate = {2021-01-01},

journal = {Journal of Hepato-Biliary-Pancreatic Sciences},

volume = {28},

number = {1},

pages = {26 – 54},

publisher = {Blackwell Publishing Asia},

abstract = {Background: The Japanese Society of Hepato-Biliary-Pancreatic Surgery launched the clinical practice guidelines for the management of biliary tract cancers (cholangiocarcinoma, gallbladder cancer, and ampullary cancer) in 2007, then published the 2nd version in 2014. Methods: In this 3rd version, clinical questions (CQs) were proposed on six topics. The recommendation, grade for recommendation, and statement for each CQ were discussed and finalized by an evidence-based approach. Recommendations were graded as Grade 1 (strong) or Grade 2 (weak) according to the concepts of the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system. Results: The 31 CQs covered the six topics: (a) prophylactic treatment, (b) diagnosis, (c) biliary drainage, (d) surgical treatment, (e) chemotherapy, and (f) radiation therapy. In the 31 CQs, 14 recommendations were rated strong and 14 recommendations weak. The remaining three CQs had no recommendation. Each CQ includes a statement of how the recommendations were graded. Conclusions: This latest guideline provides recommendations for important clinical aspects based on evidence. Future collaboration with the cancer registry will be key for assessing the guidelines and establishing new evidence. © 2020 Japanese Society of Hepato-Biliary-Pancreatic Surgery},

note = {Cited by: 41},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Alvaro20201430,

title = {Italian Clinical Practice Guidelines on Cholangiocarcinoma – Part II: Treatment},

author = {Domenico Alvaro and Cesare Hassan and Vincenzo Cardinale and Guido Carpino and Luca Fabris and Enrico Gringeri and Vincenza Granata and Massimiliano Mutignani and Helen Morement and Felice Giuliante and Alfredo Guglielmi and Lorenzo Ridola and Giuseppe Tonini and Marco Marzioni and Gianluca Grazi and Maria Guido and Emilio Di Giulio and Francesco Pantano and Rosanna Venere and Maria Consiglia Bragazzi and Francesca Biancanello and Jessica Faccioli and Aurora Giannetti and Marcello Cintolo and Michela Di Giunta and Martina Gambato and Alberto Lasagni and Francesco Izzo and Antonio Avallone and Jesus Banales and Massimo Rossi and Carlo Catalano and Andrea Laghi and Giulia D'amati and Maria Grazia Mancino},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85097004048&doi=10.1016%2fj.dld.2020.08.030&partnerID=40&md5=0d57247083149aa3927829d7d27ec2de},

doi = {10.1016/j.dld.2020.08.030},

issn = {15908658},

year  = {2020},

date = {2020-01-01},

urldate = {2020-01-01},

journal = {Digestive and Liver Disease},

volume = {52},

number = {12},

pages = {1430 – 1442},

publisher = {Elsevier B.V.},

abstract = {Currently, the only curative treatment for cholangiocarcinoma (CCA) is surgical resection, though this treatment is possible in less than 40% of patients. However, recent improvements in preoperative management have led to a higher number of patients who are candidates for this procedure. For unresectable patients, progress is ongoing in terms of locoregional and chemoradiation treatments and target therapies, especially in the definition of patient selection criteria. This is the second part of the Italian CCA guidelines, dealing with CCA treatment, that have been formulated in accordance with Italian National Institute of Health indications and developed according to the GRADE method and related advancements. © 2020 Editrice Gastroenterologica Italiana S.r.l.},

note = {Cited by: 20},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Alvaro20201282,

title = {Italian Clinical Practice Guidelines on Cholangiocarcinoma – Part I: Classification, diagnosis and staging},

author = {Domenico Alvaro and Cesare Hassan and Vincenzo Cardinale and Guido Carpino and Luca Fabris and Enrico Gringeri and Vincenza Granata and Massimiliano Mutignani and Helen Morement and Felice Giuliante and Alfredo Guglielmi and Lorenzo Ridola and Marco Marzioni and Gianluca Grazi and Maria Guido and Emilio Di Giulio and Giuseppe Tonini and Francesco Pantano and Rosanna Venere and Maria Consiglia Bragazzi and Francesca Biancanello and Jessica Faccioli and Aurora Giannetti and Marcello Cintolo and Michela Di Giunta and Martina Gambato and Alberto Lasagni and Francesco Izzo and Antonio Avallone and Jesus Banales and Massimo Rossi and Carlo Catalano and Andrea Laghi and Giulia D'amati and Maria Grazia Mancino},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090489680&doi=10.1016%2fj.dld.2020.06.045&partnerID=40&md5=506a895d20e629c0f967b85df789dea7},

doi = {10.1016/j.dld.2020.06.045},

issn = {15908658},

year  = {2020},

date = {2020-01-01},

urldate = {2020-01-01},

journal = {Digestive and Liver Disease},

volume = {52},

number = {11},

pages = {1282 – 1293},

publisher = {Elsevier B.V.},

abstract = {Cholangiocarcinoma (CCA) is the second most common primary liver cancer, characterized by a poor prognosis and resistance to chemotherapeutics. The progressive increase in CCA incidence and mortality registered worldwide in the last two decades and the need to clarify various aspects of clinical management have prompted the Italian Association for the Study of the Liver (AISF) to commission the drafting of dedicated guidelines in collaboration with a group of Italian scientific societies. These guidelines have been formulated in accordance with the Italian National Institute of Health indications and developed by following the GRADE method and related advancements. © 2020 Editrice Gastroenterologica Italiana S.r.l.},

note = {Cited by: 23},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Valle2016v28,

title = {Biliary cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up},

author = {J. W. Valle and I. Borbath and S. A. Khan and F. Huguet and T. Gruenberger and D. Arnold and On ESMO Guidelines Committee},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84995766824&doi=10.1093%2fannonc%2fmdw324&partnerID=40&md5=13cce31dda4f3895d07e2dea0d1c53d4},

doi = {10.1093/annonc/mdw324},

issn = {09237534},

year  = {2016},

date = {2016-01-01},

urldate = {2016-01-01},

journal = {Annals of Oncology},

volume = {27},

pages = {v28 – v37},

publisher = {Oxford University Press},

note = {Cited by: 329; All Open Access, Bronze Open Access},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Weber2015669,

title = {Intrahepatic Cholangiocarcinoma: Expert consensus statement},

author = {Sharon M. Weber and Dario Ribero and Eileen M. O'Reilly and Norihiro Kokudo and Masaru Miyazaki and Timothy M. Pawlik},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84936990315&doi=10.1111%2fhpb.12441&partnerID=40&md5=44758468378be4a8cbc6a6af005d471c},

doi = {10.1111/hpb.12441},

issn = {1365182X},

year  = {2015},

date = {2015-01-01},

urldate = {2015-01-01},

journal = {HPB},

volume = {17},

number = {8},

pages = {669 – 680},

publisher = {Blackwell Publishing Ltd},

abstract = {An American Hepato-Pancreato-Biliary Association (AHPBA)-sponsored consensus meeting of expert panellists met on 15 January 2014 to review current evidence on the management of intrahepatic cholangiocarcinoma (ICC) in order to establish practice guidelines and to agree on consensus statements. The treatment of ICC requires a coordinated, multidisciplinary approach to optimize survival. Biopsy is not necessary if the surgeon suspects ICC and is planning curative resection, although biopsy should be obtained before systemic or locoregional therapies are initiated. Assessment of resectability is best accomplished using cross-sectional imaging [computed tomography (CT) or magnetic resonance imaging (MRI)], but the role of positron emission tomography (PET) is unclear. Resectability in ICC is defined by the ability to completely remove the disease while leaving an adequate liver remnant. Extrahepatic disease, multiple bilobar or multicentric tumours, and lymph node metastases beyond the primary echelon are contraindications to resection. Regional lymphadenectomy should be considered a standard part of surgical therapy. In patients with high-risk features, the routine use of diagnostic laparoscopy is recommended. The preoperative diagnosis of combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CC) by imaging studies is extremely difficult. Surgical resection remains the mainstay of treatment, but survival is worse than in HCC alone. There are no adequately powered, randomized Phase III trials that can provide definitive recommendations for adjuvant therapy for ICC. Patients with high-risk features (lymphovascular invasion, multicentricity or satellitosis, large tumours) should be encouraged to enrol in clinical trials and to consider adjuvant therapy. Cisplatin plus gemcitabine represents the standard-of-care, front-line systemic therapy for metastatic ICC. Genomic analyses of biliary cancers support the development of targeted therapeutic interventions. © 2015 International Hepato-Pancreato-Biliary Association.},

note = {Cited by: 239; All Open Access, Bronze Open Access, Green Open Access},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Mansour2015691,

title = {Hilar Cholangiocarcinoma: Expert consensus statement},

author = {John C. Mansour and Thomas A. Aloia and Christopher H. Crane and Julie K. Heimbach and Masato Nagino and Jean-Nicolas Vauthey},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84936991861&doi=10.1111%2fhpb.12450&partnerID=40&md5=c91ee89909b1b8597130265eaa6ed597},

doi = {10.1111/hpb.12450},

issn = {1365182X},

year  = {2015},

date = {2015-01-01},

urldate = {2015-01-01},

journal = {HPB},

volume = {17},

number = {8},

pages = {691 – 699},

publisher = {Blackwell Publishing Ltd},

abstract = {An American Hepato-Pancreato-Biliary Association (AHPBA)-sponsored consensus meeting of expert panellists met on 15 January 2014 to review current evidence on the management of hilar cholangiocarcinoma in order to establish practice guidelines and to agree consensus statements. It was established that the treatment of patients with hilar cholangiocarcinoma requires a coordinated, multidisciplinary approach to optimize the chances for both durable survival and effective palliation. An adequate diagnostic and staging work-up includes high-quality cross-sectional imaging; however, pathologic confirmation is not required prior to resection or initiation of a liver transplant trimodal treatment protocol. The ideal treatment for suitable patients with resectable hilar malignancy is resection of the intra- and extrahepatic bile ducts, as well as resection of the involved ipsilateral liver. Preoperative biliary drainage is best achieved with percutaneous transhepatic approaches and may be indicated for patients with cholangitis, malnutrition or hepatic insufficiency. Portal vein embolization is a safe and effective strategy for increasing the future liver remnant (FLR) and is particularly useful for patients with an FLR of <30%. Selected patients with unresectable hilar cholangiocarcinoma should be evaluated for a standard trimodal protocol incorporating external beam and endoluminal radiation therapy, systemic chemotherapy and liver transplantation. Post-resection chemoradiation should be offered to patients who show high-risk features on surgical pathology. Chemoradiation is also recommended for patients with locally advanced, unresectable hilar cancers. For patients with locally recurrent or metastatic hilar cholangiocarcinoma, first-line chemotherapy with gemcitabine and cisplatin is recommended based on multiple Phase II trials and a large randomized controlled trial including a heterogeneous population of patients with biliary cancers. © 2015 International Hepato-Pancreato-Biliary Association.},

note = {Cited by: 219; All Open Access, Bronze Open Access, Green Open Access},

keywords = {},

pubstate = {published},

tppubtype = {article}

}