@article{DeCarlis20197,

title = {Past, present, and future of donation after circulatory death in Italy},

author = {Luciano De Carlis and Riccardo De Carlis and Paolo Muiesan},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85063187518&doi=10.1007%2fs13304-019-00640-5&partnerID=40&md5=286f1cf3c66cfbc674776906c3c7d090},

doi = {10.1007/s13304-019-00640-5},

issn = {2038131X},

year  = {2019},

date = {2019-01-01},

urldate = {2019-01-01},

journal = {Updates in Surgery},

volume = {71},

number = {1},

pages = {7 – 9},

publisher = {Springer-Verlag Italia s.r.l.},

note = {Cited by: 7; All Open Access, Bronze Open Access, Green Open Access},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Schlegel2018456,

title = {The UK DCD Risk Score: A new proposal to define futility in donation-after-circulatory-death liver transplantation},

author = {Andrea Schlegel and Marit Kalisvaart and Irene Scalera and Richard W. Laing and Hynek Mergental and Darius F. Mirza and Thamara Perera and John Isaac and Philipp Dutkowski and Paolo Muiesan},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85040614271&doi=10.1016%2fj.jhep.2017.10.034&partnerID=40&md5=1644f5317bd2d8ad32a918be7dbf6c0f},

doi = {10.1016/j.jhep.2017.10.034},

issn = {01688278},

year  = {2018},

date = {2018-01-01},

urldate = {2018-01-01},

journal = {Journal of Hepatology},

volume = {68},

number = {3},

pages = {456 – 464},

publisher = {Elsevier B.V.},

abstract = {Background & Aims: Primary non-function and ischaemic cholangiopathy are the most feared complications following donation-after-circulatory-death (DCD) liver transplantation. The aim of this study was to design a new score on risk assessment in liver-transplantation DCD based on donor-and-recipient parameters. Methods: Using the UK national DCD database, a risk analysis was performed in adult recipients of DCD liver grafts in the UK between 2000 and 2015 (n = 1,153). A new risk score was calculated (UK DCD Risk Score) on the basis of a regression analysis. This is validated using the United Network for Organ Sharing database (n = 1,617) and our own DCD liver-transplant database (n = 315). Finally, the new score was compared with two other available prediction systems: the DCD risk scores from the University of California, Los Angeles and King's College Hospital, London. Results: The following seven strongest predictors of DCD graft survival were identified: functional donor warm ischaemia, cold ischaemia, recipient model for end-stage liver disease, recipient age, donor age, previous orthotopic liver transplantation, and donor body mass index. A combination of these risk factors (UK DCD risk model) stratified the best recipients in terms of graft survival in the entire UK DCD database, as well as in the United Network for Organ Sharing and in our own DCD population. Importantly, the UK DCD Risk Score significantly predicted graft loss caused by primary non-function or ischaemic cholangiopathy in the futile group (>10 score points). The new prediction model demonstrated a better C statistic of 0.79 compared to the two other available systems (0.71 and 0.64, respectively). Conclusions: The UK DCD Risk Score is a reliable tool to detect high-risk and futile combinations of donor-and-recipient factors in DCD liver transplantation. It is simple to use and offers a great potential for making better decisions on which DCD graft should be rejected or may benefit from functional assessment and further optimization by machine perfusion. Lay summary: In this study, we provide a new prediction model for graft loss in donation-after-circulatory-death (DCD) liver transplantation. Based on UK national data, the new UK DCD Risk Score involves the following seven clinically relevant risk factors: donor age, donor body mass index, functional donor warm ischaemia, cold storage, recipient age, recipient laboratory model for end-stage liver disease, and retransplantation. Three risk classes were defined: low risk (0–5 points), high risk (6–10 points), and futile (>10 points). This new model stratified best in terms of graft survival compared to other available models. Futile combinations (>10 points) achieved an only very limited 1- and 5-year graft survival of 37% and less than 20%, respectively. In contrast, an excellent graft survival has been shown in low-risk combinations (≤5 points). The new model is easy to calculate at the time of liver acceptance. It may help to decide which risk combination will benefit from additional graft treatment, or which DCD liver should be declined for a certain recipient. © 2017 European Association for the Study of the Liver},

note = {Cited by: 119; All Open Access, Green Open Access},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Monbaliu2012474,

title = {Liver transplantation using Donation after Cardiac Death donors},

author = {Diethard Monbaliu and Jacques Pirenne and David Talbot},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84855929110&doi=10.1016%2fj.jhep.2011.07.004&partnerID=40&md5=7c743c10a5fa28cc76c9267b3bc03a51},

doi = {10.1016/j.jhep.2011.07.004},

issn = {01688278},

year  = {2012},

date = {2012-01-01},

urldate = {2012-01-01},

journal = {Journal of Hepatology},

volume = {56},

number = {2},

pages = {474 – 485},

publisher = {Elsevier B.V.},

abstract = {The success of solid organ transplantation has brought about burgeoning waiting lists with insufficient donation rates and substantial waiting list mortality. All countries have strived to expand donor numbers beyond the standard Donation after Brain Death (DBD). This has lead to the utilization of Donation after Cardiac Death (DCD) donors, also frequently referred to as Non-Heart Beating Donors (NHBD). Organs from these donors inevitably sustain warm ischaemic damage which varies in its extent and affects early graft function as well as graft survival. As a consequence, 'non-vital' organs such as renal transplants have increased rapidly from DCD donors but more 'vital' organ transplants such as the liver have lagged behind. However, an increasing proportion of liver transplants are now derived from DCD donors. This article covers this expansion, current results, pitfalls, and steps taken to minimize complications and to improve outcome, and future developments that are likely to occur. © 2011 Published by Elsevier B.V. on behalf of the European Association for the Study of the Liver.},

note = {Cited by: 146; All Open Access, Hybrid Gold Open Access},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Kootstra2002181,

title = {Organ donors: Heartbeating and non-heartbeating},

author = {Gauke Kootstra and Jur Kievit and Arjen Nederstigt},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0036484260&doi=10.1007%2fs00268-001-0205-2&partnerID=40&md5=4e71e1c2679e64453c037ca2ef5eadbd},

doi = {10.1007/s00268-001-0205-2},

issn = {03642313},

year  = {2002},

date = {2002-01-01},

urldate = {2002-01-01},

journal = {World Journal of Surgery},

volume = {26},

number = {2},

pages = {181 – 184},

abstract = {The limits of organ donation from heart-beating (HB) donors reached a plateau illustrated by the number of postmortem kidneys for transplantation. Programs such as the European Donor Hospital Education Program (EDHEP) and Donor Action have helped to stop a further decrease in the number instead of an expected increase. For kidneys, heart, liver, and lungs one must also explore the use of marginal donors as a possible additional source. Examples are donors with a horseshoe kidney, those at both ends of the age spectrum, and those with medical contraindication such as diabetes. We have enlarged our kidney donor pool considerably with non-heart-beating (NHB) donors. Because we preserve these kidneys in a preservation machine, we are able to perform viability testing. With glutathione S-transferase (GST) as a measure of tubular damage, we now decide whether to transplant based on GST values. For other organs, NHB donation does not seem to be an option other than for the liver when the warm ischemia time is short.},

note = {Cited by: 60; All Open Access, Bronze Open Access},

keywords = {},

pubstate = {published},

tppubtype = {article}

}