Abstract

BACKGROUND: Since 2012, Associating Liver Partition and Portal
vein ligation for Staged hepatectomy (ALPPS) has encountered
several modifications of its original technique. The primary
endpoint of this study was to analyze the trend of ALPPS in Italy
over a 10-year period. The secondary endpoint was to evaluate
factors affecting the risk of
morbidity/mortality/post-hepatectomy liver failure (PHLF).
METHODS: Data of patients submitted to ALPPS between 2012 and
2021 were identified from the ALPPS Italian Registry and
evaluation of time trends was performed. RESULTS: From 2012 to
2021, a total of 268 ALPPS were performed within 17 centers. The
number of ALPPS divided by the total number of liver resections performed by each center slightly declined (APC = - 2.0