In recent years different minimal access strategies have been designed in order to perform living donor liver surgery for adult recipients with less morbidity. Techniques involve shortening the length of the incision with or without previous laparoscopic mobilization of the liver. Herein we present two cases of totally laparoscopic living donor left hepatectomy, with and without removal of the middle hepatic vein, respectively. We describe in detail the anatomical and technical aspects of the procedure focusing on relevant points to enhance safety. The authors present two cases of full left lobe hepatectomies for living donor liver transplantation in an adolescent and an adult respectively, focusing on technical aspects and relevant hints to enhance safety. Please see online supporting information for an accompanying video. Also see editorial by Akoad and Pomfret on page 2243 and case reports on pages 2467 and 2472. © Copyright 2013 The American Society of Transplantation and the American Society of Transplant Surgeons.